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doi: 10.1007/s13105-017-0576-y

Significant decreases in liver, lung, brain tissue, and glutathione peroxidase activity were reported in rats for which pinealectomy is made [48]

For example, studies exploring midazolams oral and intravenous administration in healthy subjects reported no changes in pharmacokinetic parameters (clearance, elimination, and half-life time) after acute administration or five days of ingestion [90]

These findings support the continued development of telomere-targeted GSTP1 inhibitors for cancer therapy

This is a practical consideration, not a safety contraindication but its worth noting that the mechanisms work at cross purposes.