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However, these alterations to the microbial abundance and composition at the phylum, family and genus levels may not sufficient to adequately clarify the changes to the gut microbiota in DN patients, further investigations at the levels of species or strains are necessary in the future

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However, one report suggests that this is the case 48 , and one other study suggests that catalase could be the target of inhibitory p50 homodimers, since its promoter is bound by p50 in unstimulated cells and catalase is down-regulated when canonical NF-B activation occurs 49