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Although LOX and LOXLs are reported to significantly promote fibrotic alterations in tissues, certain stimuli are required to stimulate fibroblasts or myofibroblasts to secrete their precursors (91,92)

They're the long-established standard of care, both FDA-approved, both backed by decades of clinical data

J Neurosci 24(36):777988, PubMed PMID: 15356189 Kuroda J, Ago T, Matsushima S, Zhai P, Schneider MD, Sadoshima J (2010) NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart

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Although many of the symptoms improve with treatment, some problems caused by the condition can be irreversible if left untreated