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Normally, protection relies on both exogenous antioxidants (diet, supplements, drugs) and endogenous systems (metabolic pathways) [17,18]

Zhou Y, Zou J, Xu J, Zhou Y, Cen X, Zhao Y

Since the low-molecular-weight antioxidants glutathione (GSH) and thioredoxin (Trx-Red or Trx-SH) are cofactors of various enzymes, we may include them in the first line of antioxidant defense (Ighodaro and Akinloye 2018)

Sufficiency of mesolimbic dopamine neuron stimulation for the progression to addiction
4 Photo Credit: Freepik Vitamin E works synergistically with glutathione to protect cells from oxidative stress
