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PloS One (2016) 11(8):e0161158

The imputation approach implemented in the proposed DC Function measure uses each patient's available functional and clinical information to estimate each ANA value had the item been completed

Therapeutic doses of vitamin D can differ based on the same variables, but 50,000 IU (1,250 mcg) is a common amount according to the journal Nutrients

It is likely that many patients will require intramuscular B12 replacement for the duration of their metformin treatment, although a trial of oral replacement initially may be worthwhile.

I'm supposed to do this for 2.5 months and then report back