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The outcomes were measured using the Clinicians Erythema Assessment (CEA) by photography and an infrared thermometer to evaluate the difference in skin surface temperature (SST) of the cheeks before and after treatment

Self-administered intra-articular injection risks septic arthritis (joint infection), which requires emergency IV antibiotics and possible surgical drainage within 24-48 hours of onset

At baseline and at weeks 8 and 12, a clinician should assess fasting insulin and HOMA-IR (the homeostasis model assessment of insulin resistance, a calculated index derived from fasting glucose and insulin), HbA1c, high-sensitivity C-reactive protein as an inflammatory marker, and body composition by DEXA scan or bioelectrical impedance

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