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Interestingly, in line with data showing a circadian/hypoxia pathway crosstalk, evidence from the literature indicates the acquisition of genetic signatures involving key players both in hypoxia and circadian pathways by long-term high-altitude populations living under hypobaric hypoxia conditions 46,47
The normobaric oxygen paradox (NOP, also called hyperoxic-hypoxic paradox when considered in other than normobaric pressure) postulates that a period of hyperoxemia (obtained with normobaric or hyperbaric oxygen inhalation) followed by a return to normoxia would be interpreted by our cells as an oxygen shortage, thus potentially triggering a HIF-1 regulated gene synthesis cascade, including synthesis of EPO
Furthermore, by analyzing HNSCC biopsies with whole-genome microarrays and quantitative reverse transcriptase PCR cards, Tomkiewicz et al
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Biomaterials-enhanced intranasal delivery of drugs as a direct route for brain targeting
