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Description
Haematological manifestations typically appear first
Sebaceous hyperplasia is seen more commonly in the male population and more specifically in Caucasian males
The synergy between the two receptor pathways is present even at low doses, which is an argument for tirzepatide-based microdosing over semaglutide-based microdosing from a metabolic standpoint
In 3T3-L1 cells, expression of TGH is upregulated tenfold upon differentiation of preadipocytes into adipocytes (25) due, at least in part, to transcriptional regulation by the adipogenic transcription factor C/EBP (136)
This can contribute to weight management and overall metabolic health
