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Several proteases, including matrix metalloproteainse 2 (MMP-2), have been shown to be upregulated in many cancers [22, 23]

Because the transsulfuration pathway consumes SAM without replenishing methionine, its hyperactivity leads to reduced SAM availability ( The dysregulation of one-carbon metabolism and DNA hypomethylation caused by alcohol is implicated in the development of alcohol-induced liver disease (ALD) ( Interestingly, pharmacological restoration of effective one-carbon metabolism after chronic alcohol consumption may treat alcohol-induced liver injury

As these neutrophils squeeze between the cells, they release HOCl, which can react with GSH secreted from the epithelial cells that normally protects the epithelial cells (Venglarik et al., 2003)

Exercise has demonstrated the capacity to reduce the overexpression of the MiT/TFE gene in patients afflicted with renal, pancreatic, and melanoma cancer, resulting in the inhibition of cancer cell proliferation [95]

Extent of N-terminus exposure of monomeric alpha-synuclein determines its aggregation propensity