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ABLA stands for acute blood loss anemia, a clinical shorthand used in emergency and surgical settings

In one aspect of the invention, one or more NNMT inhibitors (such as a cation of Formula I or IA, or otherwise disclosed herein) is contacted with a cell expressing NNMT concurrently with one or more chemical entities (e.g., nicotinamide riboside, nicotinamide mononucleotide) that increase intracellular NAD+ levels to provide muscular therapy

5-amino-1mq, or 5-amino-1-methylquinolinium, is a synthetic small molecule compound that targets a specific enzyme involved in metabolic regulation

it is also a major NAD + consumer with a lower K m than most NAD + -consuming enzymes 40 and is implicated in the decline of NAD + levels observed during aging and disease 5052

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