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Referral for specialist consultation is appropriate if first-line therapy fails or HS is severe

The chromosome 1q21.3 variants, rs2228145 and rs4129267, characterised by a nonsynonymous SNP, are linked to elevated plasma soluble (s)IL-6R levels [67, 68], which is more commonly observed in individuals of the neutrophilic and mixed granulocytic subtypes [69]

C-reactive protein levels and outcomes after statin therapy

Large-scale syntheses of clinical data on multidrug-resistant Gram-negative infections similarly conclude that new BL/BLI combinations and cefiderocol have shiftedbut not eliminatedthe high-risk nature of these infections, and that resistance to these agents is already being reported (Macesic et al., 2025

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