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However, human clinical trials specifically for disc herniations are limited, so definitive claims about disc healing in humans cannot yet be made

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Further complicating the matter, in brewing yeast there exists more complete and less complete versions of the IRC7 gene (long and short versions), differing levels of intact promoter regions (which effectively turn on the gene), and differing allelic profiles (how the gene is carried on different chromosomes) all of these things affect the level of activity of this -lyase enzyme

Human data remain limited to case reports, so efficacy in clinical practice is still under evaluation

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