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Glycolysis produces only 2 ATP molecules, but somewhere between 30 and 36 ATPs are produced by the oxidative phosphorylation of the 10 NADH and 2 succinate molecules made by converting one molecule of glucose to carbon dioxide and water, [5] while each cycle of beta oxidation of a fatty acid yields about 14 ATPs

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These findings suggest that a large variety of degrading enzymes are involved in controlling ECM proteolytic activity and barrier integrity and that a deeper investigation of their functions is warranted to further our understanding of IBD pathophysiology

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As this trial focused on the effects of marizomib in kidney cancer cells, future studies may also explore the effects of Marizomib on other tumor cells associated with HLRCC