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If the entire bodys vascular endothelium could be collected, the total weight would be equivalent to that of the liver, and if it could be spread over an entire surface, the total area would be equivalent to six tennis courts, and it would be 100,000 km or two and a half times around the earth if it could be connected in a single row [6]

Altered microbial composition, termed dysbiosis, has been implicated in mucosal barrier dysfunction and inflammatory responses, which predispose the host animals to systemic diseases (e.g., inflammatory bowel disease, celiac disease, food allergy, obesity, and autoimmune diseases) (18)

Accordingly, in order to control the severity of the COVID-19 and prevent its transcription, we must control the activity of the nuclear factor-kappa B