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The therapeutic strategy mentioned in the text involves targeting immune organs to counteract immunosenescence by restoring thymic vitality, rejuvenating bone marrow niches, and improving the function of peripheral immune organs, ultimately enhancing the generation and functionality of immune cells

Nat Methods 5 , 763775, (2008)

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The high PRLR expression in clinical DCIS and preneoplastic structures in preclinical models is reminiscent of ER expression in many of these lesions [reviewed in (183)], and suggests a role for PRL at this early stage of the disease process

Selenomethionine alleviates T-2 toxin-induced articular chondrocyte ferroptosis via the system Xc-/GSH/GPX4 axis