melanotic macules definition macule. Benign. Dark spot on labia (or lip). Analogous to lentigo simplex. Hyperpigmented basal keratinocytes & dermal melanophages. Slight ⬆️ in single basal melanocytes; NO nests. More info like this in Melanotic Macules, Naevi, and Melanoma

Without any clear rationale, the study outcome measures were purposefully modified midtrial to alter the findings in favour of their hypothesis (549, 550)

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J Vasc Med Surg 2(4):14 Hegde S, Akbar H, Zheng Y, Cancelas JA (2018) Towards increasing shelf life and haemostatic potency of stored platelet concentrates

A definitive activity remained elusive for many years as conflicting reports described CRP as both pro- and anti-inflammatory activities, and as both pro- and anti-thrombotic [reviewed in ( The confusion concerning CRP's bioactivities only recently began to clarify when it was recognized that the serum soluble non-covalently associated pentameric CRP structure could be induced to dissociate into monomeric subunits

Once activated, these receptors trigger a cascade of cellular signalling that ultimately increases the production and release of eumelanin, the dark pigment responsible for tanning