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While refrigeration can't stop this, the overall slowdown of chemical reactions helps mitigate the damage

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SAM is involved in hundreds of methylation reactions throughout the body, and the systemic effects of preserving SAM through NNMT inhibition in tissues beyond adipose tissue remain unknown

Recent insights into the gutbrain and lungbrain axes highlight how abnormal intestinal microbiota, altered mucosal immunity, and even lung complications can exacerbate neuroinflammation and worsen outcomes after ischemic stroke (Xie et al., 2024)

In addition, inhibiting METTL17 significantly reduces mitochondrial RNA methylation, impairing the translation of mitochondrial protein-coding genes, affecting mitochondrial energy metabolism, and enhancing mitochondrial and intracellular ROS and lipid peroxidation levels