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Anti-adipogenic effects of delphinidin-3-O-glucoside in 3T3-L1 preadipocytes and primary white adipocytes

Developed at the University of Arizona, it is a cyclic lactam analogue of -MSH with the amino acid sequence Ac-Nle- cyclo [Asp-His--Phe-Arg-Trp-Lys]-NH 2

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Blood 103(12):4396-4407, 2004

These changes facilitated the recruitment and activation of macrophages and myofibroblast-like cells in the liver, leading to increased collagen deposition and the progression of liver fibrosis