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While certain senolytic compounds have shown specificity for senescent cells in preclinical models, achieving this selectivity in humans remains a significant hurdle.120 For example, some senescence-associated proteins (eg, BCL-2, p53, SASP factors) are also expressed in normal, proliferating cells, leading to potential off-target effects.31 Therefore, optimizing senolytic agents to minimize side effects while maintaining efficacy is crucial

In: New York: Oxford University Press

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Theres a little bit of human evidence as well that it improves cognition, not strong, but again, we just dont have a lot of people researching it