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doi: 10.1085/jgp.200609552
NguyenTTTTsujiguchiHKambayashiYHaraAMiyagiSYamadaYet al
& Basson, C
Or Are Both Caused by Insulin Resistance
Absent Fn3K, NRF2 is glycated, a post-translational modification which enhances KEAP1-driven degradation, impairs NRF2 binding to transcriptional cofactors sMAF, reduces NRF2 binding in the promoter region of target genes, and leads to reduced transcription of canonical NRF2 pathway genes [87]
