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The permanent increase in plasma glucose diverts into the polyol, hexosamine, and pyruvate pathways, and the enzymes aldose reductase and sorbitol dehydrogenase convert it into sorbitol and fructose

Galloway JA (Medical Research Division, Eli Lilly and Company, Indianapolis, IN): Personal communication

Reactivity Testing : The reactivity of urate hydroperoxide with various free amino acids (taurine, histidine, lysine, tryptophan, methionine, cysteine, and glutathione) was studied by incubating urate hydroperoxide with these amino acids and analyzing the products by HPLC and LC-MS/MS

These have been reported to lead to impaired GH release (96) or to alter folding of GH (97)