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Daratumumab depletes CD38+ immune regulatory cells, promotes T-cell expansion, and skews T-cell repertoire in multiple myeloma

Four patients (~20%) had a reduced frequency of cytotoxic CD56 dim NK cells together with an altered BM NK transcriptome that featured enriched expression of genes encoding enrichment of inhibitory receptors ( KLRB1 and KLRC1 ) and decreased expression of genes encoding activating receptors such as FCGR3A (CD16), NCR3 (NKp30), and CD226 (DNAM1)

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At the forefront of regenerative medicine, BPC-157, or Body Protective Compound-157, is a peptide derived from a protein found in the stomach

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