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Table 2 aims to yield a direct comparison between various nanoformulations and address BBB transport mechanism, toxicity profile along with translational considerations

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MOTS-c with Mannitol consists of 16 amino acids, and it belongs to the family of the mitochondrial-derived peptides, bioactive hormones, which are important for mitochondrial communication, and energy regulation

It also inhibited the p53 signaling pathway in the intestine while activating peroxisome proliferator activated receptor (PPAR) signaling and fatty acid metabolism in the liver, highlighting its role in gut-liver axis regulation (Li M