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Types of vesicles used such as MLV, SUV or large unilamellar vesicles (LUV) and their encapsulation efficiency varies greatly from 1% for SUVs to 88% for MLVs

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Thiamine is especially important for alcohol and drug detox, because chronic alcohol use causes thiamine deficiency, which leads to Wernickes encephalopathy and Korsakoff syndrome, as studied by Martin PR, Singleton CK, Hiller-Sturmhfel S

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Confounding variables, such as diet and environmental exposures, complicate comparisons