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Description
MECHANISM CATEGORIES RESEARCH CONDITIONS SAFETY Side effects Limited human safety data Animal studies report wide therapeutic window Known interactions Methyl-donor depletion theoretical with chronic dosing (NNMT methylates nicotinamide using SAM) Contraindications Pregnancy/lactation (unstudied) REGULATORY STATUS FDA Not FDA-approved

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Methylation Capacity Second, NNMT inhibition affects cellular methylation capacity: SAM is required for hundreds of methyltransferase reactions throughout the cell, and NNMT's consumption of SAM can deplete this critical resource, while the SAH produced by NNMT is a potent product inhibitor of many methyltransferases

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