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[8] [12] [30] Transaldolase Transaldolase was discovered in 1953 by Horecker and Smyrniotis in brewers yeast, identified as Saccharomyces cerevisiae

Here is a realistic timeline based on clinical observations: A few things to keep in mind

doi: 10.1016/j.hsr.2024.100196
Densitometric analysis of lens transparency indicated that patients treated with pirenoxine showed a minor optical density in the anterior and posterior cortical lens layers and underneath the posterior capsule in the first months of treatment compared to cataract patients and the transparency remained unchanged in the other lens layers [70]
