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However, clinical trials have shown that xCT inhibitors are ineffective in patients with glioma and have numerous SASP-related side effects, which highlights the need for further clinical trials in patients with high tumor burdens (90)

A growing body of evidence has demonstrated that kynurenine pathway activity is generally increased in COPD and its acute exacerbations: the KYN/TRP ratio has been found to be elevated in peripheral blood or respiratory samples in several studies and is associated with inflammatory markers, suggesting a potential role of this pathway in the inflammation-metabolism crosstalk in COPD

[DOI] [PMC free article] [PubMed] [Google Scholar] 134.Moinova HR, Mulcahy RT

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Adenosine A2 receptor activation ameliorates mitochondrial oxidative stress upon reperfusion through the posttranslational modification of NDUFV2 subunit of complex I in the heart