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The lipid carriers can be used for the coming vaccines with changes in the mRNA sequence only

J Clin Oncol 20(21):43194323 Rajkumar SV et al (2010) Lenalidomide plus high-dose dexamethasone versus lenalidomide plus low-dose dexamethasone as initial therapy for newly diagnosed multiple myeloma: an open-label randomised controlled trial

Similarly, another study showed that DNMT1 deletion leads to genomic instability and cell death in both murine and human cells

And the consequences of that gap are silent

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