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Nat Med (2023) 29(5):118090

found that patients with T2DM, hyperlipidemia, coronary artery disease, polycystic ovary disease (PCOD), or obesity, and on metformin therapy were significantly associated with increased risk of vitamin B 12 deficiency and lower serum vitamin B 12 concentrations [9]

The central nervous system is protected by what is known as the blood-brain barrier (BBB), which prevents toxic molecules from reaching the brain, but also limits the accumulation of drugs in therapeutic doses

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