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Development of an in vivo murine model to evaluate the efficacy of small molecule inhibitors for the treatment of leukemic cells with activated MAPK/ERK signaling

doi: 10.1073/pnas.1819728116 98 ZhuSZhangQSunXZehHJLotzeMTKangRet al

doi: 10.1016/j.cbi.2008.07.009 111 SinghUDevarajSJialalI

The metabolic plasticity of cancer is not restricted only to cancer cells but extends throughout the TME (184, 185), as seen in CAFs that secrete lactate, lung mesenchymal-derived cells that transfer lipids, suppressing the functioning of NK cells, and arginine-depleting collagen-producing TAMs, leading to the suppression of CD8 + T cell functions

Consult your doctor before starting, and tell them about any pre-existing conditions or other medicines you take
