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The evidence base consists primarily of animal studies with limited human clinical data

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92 1033910343 10.1073/pnas.92.22.10339 [DOI] [PMC free article] [PubMed] [Google Scholar] Nakagawa T., Shimizu S., Watanabe T., Yamaguchi O., Otsu K., Yamagata H., et al

It may involve an inborn defect in -glutamyl pathway of glutathione synthesis (controlled by cellular factor) or other exogenous or endogenous agents such as the local microbes (already explained).[29] More recently, Grant et al .,[82] reported improvement in glutathione concentrations in GCF following periodontal therapy from 1182 711 M to 1424 554 M [Table 4]

leaf extract, which effectively protected zebrafish from scopolamine-induced memory impairments, highlighting its cognitive-enhancing effects (Amoah et al., 2023)