glutathione production in bacteria Ampicillin Exposure and Deficiency Synergistically Promote Conjugative Transfer of Plasmid‐Borne Antibiotic Resistance Genes - Chen - 2025 - Environmental Microbiology GLUTATHIONE SYNTHESIS - PMC

Cell 184 , 14551468 (2021)

(2015) described the development of angiotensin IV analogs including Dihexa and their HGF/c-Met potentiation mechanism (PMID: 25455861) Expression of Concern: The landmark 2012 paper describing Dihexa's cognitive effects received an expression of concern from the journal (PMID: 34551989), citing data integrity issues including questioned Western blot images Retraction: A follow-up paper from the same research group was retracted (PMID: 40312093), further undermining the evidence base for Dihexa's reported effects No Human Studies: No clinical trials, pharmacokinetic studies, or safety assessments have been conducted in humans Limited Independent Replication: The core claims about Dihexa's cognitive-enhancing effects have not been independently replicated by groups outside the original laboratory The Evidence Gap: This comparison starkly illustrates the difference between a compound with decades of clinical validation (Cerebrolysin) and one with provocative preclinical data undermined by integrity concerns (Dihexa)

visualization, B.B., D.E.L

In vivo sepsis model Sepsis was induced in C57BL/6J mice by intraperitoneal (IP) injection with LPS (10 mg/kg) for 2 hr followed by 100 mM/100l, pH 7.4 ATP (Sigma-Aldrich, A7699) IP injection as previously described (53)

[DOI] [PubMed] [Google Scholar] 1267.Taylor EL, Rossi AG, Shaw CA, Dal Rio FP, Haslett C, Megson IL