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Discovered in 2015, it has become a central tool in research on AMPK signalling, metabolic homeostasis, and mitochondrial-nuclear crosstalk

Thus, further studies on a diverse set of in silico, in vitro, and in vivo animal models are required and standardization of the pathognomic behavioral assay in order to establish pathogenic hotspot of disease and to evaluate the novel dietary/metabolic therapy that can provide insight into the neurobiology of ASD is warranted

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