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The cytoplasmic RNA puncta were less diffuse with tethered PGL-1 than in the control and frequently colocalized with PGL-1::SNAP::N22 in perinuclear granules (Supplementary Fig

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4-HNE, 4-hydroxynonenal
Therefore, it is suggested that HB or combined KBs arising from different types of KDs mitigate reactive astrogliosis and reduce the levels of GFAP in circulation