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Spatial omics technologies, particularly the 10x Visium platform, have enabled simultaneous profiling of mitochondrial metabolic states and immune cell infiltration patterns at anatomical resolution, facilitating the initial construction of spatially resolved metabolismimmune interaction maps [168].In parallel, proteomics is increasingly recognized as a critical complement to transcriptomic and metabolomic data

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(2) systemic mechanisms including gutbrain, erythrocytebrain, and kidneybrain axes