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[DOI] [Google Scholar] 76.Pleguezuelos-Villa M., Mir-Palomo S., Dez-Sales O., Ofelia Vila Buso M.A., Ruiz Sauri A., Ncher A

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The transcription factor nuclear factor E2-related factor 2 (Nrf2) is a major regulator responsible for the expression of a series of antioxidant genes involved in antioxidant response pathways, including iron-dependent ROS production, GSH homeostasis, and GPX4 activity (8)

In the diet, lignans often occur as complex precursors (like secoisolariciresinol diglucoside in flax) that are metabolized by gut microbiota into bioactive forms (54)

The SPRINT trial, composed of 9,361 patients randomized into intensive and standard blood pressure control with the primary outcome being a composite of severe cardiovascular events
