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Increased oxidative stress from low levels in older people can make the bones more fragile and contribute to osteoporosis

Two other studies found that TCR signaling was inhibited by cholesterol (87) or cholesterol sulfate (88) either via binding to the TCR transmembrane region to prevent switching to the active conformation or disrupting TCR multimers by replacing cholesterol bound to the TCR-CD3 complex, respectively

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Functionalization of nanoparticles with targeting ligands, such as antibodies or peptides, allows for site-specific accumulation and cellular internalization of the peptide cargo