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In contrast to B1 and MZB cells, FoB cells are largely considered pro-atherogenic and produce high affinity IgG OSE

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Neurosurgery 1995;37:1080-7

Tumor-specific T cell dysfunction is a dynamic antigen-driven differentiation program initiated early during tumorigenesis

Subsequently, the biotin group in these labeled peptides will be cleaved off by either enzymes (isoTOP-BPP approach) or UV (QTRP and DiaAlk approaches) at a specific wavelength, allowing labeled peptides to be readily analyzed by LC-MS/MS (see Figure 6)