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This makes IGF-1 LR3 the only viable option for GH-independent anabolic signalling studies

However, SLC30A10 and SLC30A1 have key differences in their functions, as the former is primarily a Mn transporter, while the latter is primarily a Zn transporter 84,85,86,87

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Hence, tier-2 targets follow a similar strategy to chemotherapeutics in cancer, which often impair regular cellular metabolic activity