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The reality is that that what the FDA means by safety is a matter of regulatory compliance (large scale clinical trials, manufacturing standards, etc.) not toxicity

Vitamin B12 supplementation during pregnancy and postpartum improves B12 status of both mothers and infants but vaccine response in mothers only: a randomized clinical trial in Bangladesh

Nicotinamide (Vitamin B3): Smooth overall skin texture & brighten skin
Wainwright P (2017) Q&A: Metformin and vitamin B12 deficiency

But low risk doesnt mean zero risk
