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It is theorized that TMAO prevents of excess cholesterol from being excreted, thus allowing it to infiltrate artery walls, which is being studied as a possible culprit for increased risk of cardiovascular disease

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[DOI] [PMC free article] [PubMed] [Google Scholar] Gillett K, Harshberger E, Valdez GR (2013) Protracted withdrawal from ethanol and enhanced responsiveness stress: Regulation via the dynorphin/kappa opioid receptor system
