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Even the blood-brain barrier cannot defend against them, and studies have found that plastic particles accumulated in the brain tissue, easily crossing the blood-brain barrier in mice (Shan, et al, 2022)
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Similarly, pharmacological inhibition of HSL and knockdown of PNPLA2 reduced the expression of known PPAR target genes in which LDs were shown to be a source of PPAR and PPAR ligands that could be generated within minutes of stimulating lipolysis (3)
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