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The primary mechanism by which metformin interferes with vitamin B12 absorption involves calcium-dependent membrane action in the terminal ileum, where vitamin B12 is absorbed

Why B12 Injections May Work Better Than Oral Supplements Vitamin B12 absorption in the digestive tract is complex

Frequently asked questions Our team of experts has the answers you're looking for

This means oral supplementation with crystalline B12 can be effective even when food-bound B12 absorption is impaired

Medication Use Certain medications, such as proton pump inhibitors (PPIs) for acid reflux or metformin for diabetes, can interfere with B12 absorption