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The following serious adverse reactions are described elsewhere in the labeling: Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice

doi:10.1017/s0007114515000227 Ashor AW, Brown R, Keenan PD, Willis ND, Siervo M, Mathers JC

About the Ontario Health Technology Assessment Series To conduct its comprehensive analyses, Evidence Development and Standards and its research partners review the available scientific literature, making every effort to consider all relevant national and international research

doi: 10.1371/journal.pone.0190035