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Beyond the demonstration that pharmacologic blockade of IGF-1R signaling can favorably impact lifespan, these data also provide new insights into temporal and metabolic aspects regarding this pathway and aging

Reprod 2007, 77, 492503

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doi: 10.1038/nrc.2016.81 62 YangYWuJCaiJHeZYuanJZhuXet al

In iron metabolism, to block iron entry into the brain, knockdown of Nrf2 reduces FPN expression on BMECs and may serve as a means to avoid brain iron overload (Han et al