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Disruption in the balance of cell competition results in winner cells and loser cells, where loser cells experience slowed proliferation and incomplete apoptosis, while winner cells exhibit accelerated proliferation (271, 272)
Frontiers in Bioscience
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Activation of CaMK4 in cortical neurons reduces synaptic strength and spontaneous firing rates whereas CaMK4 inhibition increases both, which suggests that CaMK4 activation generates a negative feedback signal that controls neuronal firing rates [104]
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