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Description
A pharmacologic strategy for overcoming poor BBB permeability and/or efflux out of the brain of organic acid-based, small molecule therapeutics such as NAC is co-administration with a targeted or nonselective membrane transporter inhibitor
In addition, advanced nanoformulations and structural analogs have enhanced their bioavailability and therapeutic reach
Who should consider it
Carnitine deficiency was significantly associated with increased intradialytic symptoms, including muscle spasms and hypotension
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