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In stark contrast, the mechanism of action of MK-777 is rooted in the central nervous system, where it acts as a selective ligand for specific subtypes of serotonin receptors

Interestingly, SFN restores the compromised mitochondrial membrane potential in PINK1-deficient cells and protects them against dopamine toxicity [484], suggesting that the role of Nrf2 in mitochondrial function [149, 174] may constitute part of the protective mechanism of pharmacological Nrf2 activators in Parkinson disease

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The samples were incubated at room temperature