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Glutathione depletion and disruption of intracellular ionic homeostasis regulate lymphoid cell apoptosis

However, the subcellular distribution of CoQ 10 is asymmetrical, since most of this quinone is located in the inner mitochondrial membrane (4050%), and to a lesser extent in other organelles such as the Golgi, endoplasmic reticulum or lysosomes

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Selenium deficiency can be caused by intestinal malabsorption or increased loss through diarrhea, which may be symptoms of cancer or can be associated with anti-cancer treatment (including radiotherapy and gastrointestinal surgery) (376, 377)