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In fact, the loss of FH has been previously associated with the increased production of reactive oxygen species (ROS) 9 , and the accumulation of fumarate in FH-deficient cancer cell lines leads to the formation of an adduct between fumarate and glutathione (GSH), which depletes intracellular NADPH and enhances oxidative stress 10

[DOI] [PMC free article] [PubMed] [Google Scholar] [123].Amend A, Wickli N, Schfer AL

2025;47:e00512

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